The Little Black Dress Reinvented By You: Bow & Drape Reworks A Fashion Clich

Technology is quickly disrupting one of the oldest industries in the country, fashion. And customization is at the heart of that, whether it's personalized web fittings or Indie boutique pieces via Etsy or completely customized clothing. Bow & Drape, a company we met in Boston, is ready to rethink the way you shop for dresses. In essence, Bow & Drape lets you start with a silhouette — A line, drop-waist, or whatever — and continue customizing from there. You can select the hemline, color, sleeve-length, and add special accoutrements like beads. The site asks for a quick set of body measurements before you get too in-depth to make sure that whatever you choose will fit like a glove.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/-fznnHcW3e8/

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Psychiatrists OK vast changes to diagnosis manual

CHICAGO (AP) ? For the first time in almost two decades the nation's psychiatrists are changing the guidebook they use to diagnose mental disorders. Among the most controversial proposed changes: Dropping certain familiar terms like Asperger's disorder and dyslexia and calling frequent, severe temper tantrums a mental illness.

The board of trustees for the American Psychiatric Association voted Saturday in suburban Washington, D.C., on scores of revisions that have been in the works for several years. Details will come next May when the group's fifth diagnostic manual is published.

The trustees made the final decision on what proposals made the cut; recommendations came from experts in several task force groups assigned to evaluate different mental illnesses.

Board members were tightlipped about the update, but its impact will be huge, affecting millions of children and adults worldwide.

The manual "defines what constellations of symptoms health care professionals recognize as mental disorders and more importantly ... shapes who will receive what treatment. Even seemingly subtle changes to the criteria can have substantial effects on patterns of care," said Dr. Mark Olfson, a Columbia University psychiatry professor who was not involved in the revision process.

The manual also is important for the insurance industry in deciding what treatment to pay for, and it helps schools decide how to allot special education.

The guidebook's official title is the Diagnostic and Statistical Manual of Mental Disorders. The new one is the fifth edition, known as the DSM-5. A 2000 edition made minor changes but the last major edition was published in 1994.

The manual "seeks to capture the current state of knowledge of psychiatric disorders. Since 2000 ... there have been important advances in our understanding of the nature of psychiatric disorders," Olfson said.

Expected changes include formally adopting a term for children and adults with autism ? "autism spectrum disorder," encompassing those with severe autism, who often don't talk or interact, and those with mild forms including Asperger's. Asperger's patients often have high intelligence and vast knowledge on quirky subjects but lack social skills.

Some Asperger's families opposed the change, fearing their kids would lose a diagnosis and no longer be eligible for special services. And some older Asperger's patients who embrace their quirkiness vowed to continue to use the label.

But experts say the change won't affect the special services available to this group.

Catherine Lord, an autism expert at Weill Cornell Medical College who was on the psychiatric group's autism task force, said anyone who met criteria for Asperger's in the old manual would be included in the recommended new diagnosis.

One reason for the recommended change is that in some states and some school systems, children and adults with Asperger's receive no services or fewer services than those given an autism diagnosis, she said.

Other proposed changes include:

?A new diagnosis ? disruptive mood dysregulation disorder, which critics argued would medicalize kids' normal temper tantrums. Supporters said it would address concerns about too many kids being misdiagnosed with bipolar disorder and treated with powerful psychiatric drugs. Bipolar disorder involves sharp mood swings from feeling sad and depressed to unusually happy or energetic. Affected children are sometimes very irritable or have explosive tantrums. The new diagnosis would be given to children and adults who can't control their emotions and have frequent temper outbursts in inappropriate situations.

?Eliminating the term "dyslexia," a reading disorder that causes difficulty understanding letters and recognizing written words. The term would be encompassed in a broader learning disorder category.

?Eliminating the term "gender identity disorder." It has been used for children or adults who strongly believe that they were born the wrong gender ? they dispute their normal biological anatomy. But many activists believe the condition isn't a disorder and say calling it one is stigmatizing. The term would be replaced with "gender dysphoria," which means emotional distress over one's gender. Supporters equated the change with removing homosexuality as a mental illness in the diagnostic manual, which happened decades ago.

___

Online:

Diagnostic manual: http://www.dsm5.org

___

AP Medical Writer Lindsey Tanner can be reached at http://www.twitter.com/LindseyTanner

Source: http://news.yahoo.com/psychiatrists-ok-vast-changes-diagnosis-manual-194448645.html

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grange genna: Reference and Education Posting Category - May ...

This can be a perspective comparable to creativity expert Ken Robinson's analysis about how precisely people lose power they have to ponder the possible uses of a paper clip since they grow older, simply because they stop communicating with them about the nature of the paper clip. Comforting news for such people is that government is providing a lot of grants and support if you're going through their studies. Presently the education sector with the nation has good openings for numerous educated youth in the country. All the students are strictly necessary to follow the proper time table of the school to keep up the regularity and worthiness within their work. You are certainly not required to appear for any written entrance exam for admission into most with the B. masterdegrees-online.com And today, the greatest question personally is, how is it that anyone get going to a school to gain elementary education, when that education is performing no good to him inside future.

A career in the relevant field of studies may be the first choice. Find employment in the kind of type of cooking that interests you. With the standard of education getting higher, an organization's demand with an individual's a higher level education can be getting higher. It therefore needs to be taken being a subject taught in schools to further improve knowledge around the subject matter; something merely as human anatomy or biology class. - make a detailed list in the pros along with the cons and consider your future carefully. The biggest educational centre in the country is Delhi. schools listing

The educators are expected to teach subjects like English, mathematics, basic science, history, geography along with a different language. India should think carefully just how much foreign system of education has helped her. (3) Politicizing education: Merit isn't any longer regarded as it really is now " individual preference know" and never "what it is possible to deliver" Technocrats (educationists usually are not appointed Commissioner of education and education board). The exam is conducted to recruit the educated youth with the nation inside post of teachers as well as non teaching positions in several government affiliated schools all across the nation. These teachers aren't only expert within their teaching concepts and also they know the deep child psychology. The reasons for every state is the education of the company's youth.

What will be the gaps in education that you simply want assembling your shed to resolve using the help of a funding assistance. The team of professionals at Distance learning India has vast experience within the field of providing Distance Education using the easiest mode of learning. This also designed a bond among people of India which can be keeping this country together. It is one from the best and widely preferred education companies that are considered as a global leader in the field of training and development. The locals here are provided with the most effective possible public amenities and privileges. Teflon shaft seal, ceramic shaft seal and lubricated shaft seals (Buna, Teflon, Viton) are standard.

This means enrollment in an accredited college, university, vocational school, and other accredited postsecondary educational institution. This system Improves communication at all levels inside the institution in order to align the organization with the higher standards institutional goals. Once they are shown a true picture of sex and its particular consequences their mental status relaxes and they are easily able to cope with other social taboos. In addition, if it condition is not met inside a period of eight years after graduation, a student will be required to pay back the grant cash with interest. Money thus availed from grants might be used for paying tuition fees, buying books, buying study materials, arranging housing facilities etc. All the various components and sections in the question paper must be studied with equal emphasis. Thousands of individuals are signing up a year to take classes online since they allow these to continue with their life and receive education at the identical time.

Source: https://wiki.waratah.spcc.nsw.edu.au/groups/2012bathursttripmccowenb/weblog/b087a/

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Small Business Owners Rally Tax Cuts | KREX - News, Weather ...

Story Created: Dec 1, 2012 at 7:54 PM MST

Story Updated: Dec 1, 2012 at 10:55 PM MST

GRAND JUNCTION, Colo.- A group of small business owners and local residents gathered outside the Mesa County Courthouse Saturday to fight to retain middle class tax cuts.

December 31 is an important day for many Americans, as it's the day the Bush Tax Cuts are expected to expire.

"We can have a thriving economy and keep creating jobs if the wealthiest two percent of Americans pay for their fair share," said Courtney Law, spokesperson for protect your care Colorado.

Residents rallying had two messages. One, to support the middle class continuation of the Bush Tax Cuts, which would ease the tax burden for folks making less than $250,000 a year. Two, ending the Bush Tax Cuts for those making $250,000 a year or more; ultimately raising their taxes by nearly four percent.

"The middle class are the ones who support this country and they need to stand and say, 'get this bill passed'," said Maria Keenan, owner of Keenan Construction.

Bill 3412, called the "Middle Class Tax Cut Act", supports what the residents stood for during the rally. The bill has already passed the senate, and is waiting for approval in the house.

Some residents say if the bill doesn't pass, the average tax payer will pay about $2,200 more a year.

"I'll have to pay a little more in taxes which is okay but for the people who have children, and are struggling, it's going to be hard for them to do that," said Keenan.

Source: http://www.krextv.com/news/around-the-region/Small-Business-Owners-Rally-Tax-Cuts-181705471.html

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Increase PPC & SEO Conversion With Email Nurture | You Love ...

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In brick-and-mortar retail, there are hundreds of years of well-studied consumer function to beam shopkeepers. For example, putting tack equipment such as divert during a behind of a preference store so that congregation travel by other equipment they didn?t intend to buy. ?Kids Eat Free Night? is a gimmick to settle family dining patterns that are famous to repeat.

But a online universe is comparatively immature and tiny business online selling norms are still developing.

73 Percent of Inbound Leads Aren?t Sales-Ready

With so many importance on generating leads, it?s easy to remove steer of a genuine goal. The existence is that acclimatisation is frequency a discerning event. It takes nurturing. No matter how good a onsite knowledge is, it?s critical that an online selling plan commend that a sale will be in several parts.

Online Marketers Use Email Poorly

Forty percent of marketers don?t use email for season nurturing. There are also many businesses who still trust that shopping a outrageous email list to use for a enchanting ?blast? of new business will work. It won?t.

Eighty-one percent of marketers use email for initial lead generation. But mostly with bad results.

Email used wrong is an outbound selling technique. Used correctly, email is an glorious element to a tiny business online selling strategy. But few tiny businesses know this distinction. This means targeting recipients who will indeed be meddlesome in a product and nurturing those who have already shown an interest.

Email Marketing Increases PPC SEO Conversion

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With a costs of pay-per-click (PPC) promotion and hunt engine optimization (SEO) efforts rising, a importance of a tiny business online selling debate will increasingly spin to conversion. This can be a bit confusing. If SEO or PPC generates an initial tiny business lead, though it is one of a 73 percent that isn?t sales-ready, a lead contingency afterwards be nurtured after a initial indicate of contact.

Email is a many effective nurturing resource by far. When a successive email, maybe a third or fourth in a nurturing series, brings a awaiting behind to squeeze ? is that acclimatisation due to email? Regardless of how a lead is categorized, tiny business should use an integrated selling dashboard so they can magnitude this formidable selling function and know it.

Conclusions

To put it in soccer terms, a support is mostly as critical as a goal. In other words, a tiny business online selling debate needs to commend that 73 percent of leads won?t be prepared to squeeze on a spot.

SEO and PPC leads both need to be nurtured after a initial indicate of hit to move a ultimate acclimatisation rate up. This formidable set of online behaviors needs to be well-tracked to equivocate vouchsafing a intensity patron travel out of a practical store empty-handed.

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Molecular knock-out alleviates Alzheimer's symptoms in mice

ScienceDaily (Nov. 30, 2012) ? Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the University Medical Center G?ttingen (UMG) have identified an enzyme as a possible target for the treatment of Alzheimer's disease. The protein known as HDAC6 impairs transport processes within the nerve cells. The scientists observed only mild symptoms of the disease in mice if the enzyme was not produced. They propose to block its activity in a targeted fashion to treat the disease. Scientists from the DZNE sites in G?ttingen and Bonn, the UMG as well as from the US participated in this basic research project on Alzheimer's disease.

The study is published in EMBO Molecular Medicine.

The researchers led by Prof. Andr? Fischer, Department of Psychiatry and Psychotherapy at the University Medical Center Gottingen and Site Speaker of the DZNE in G?ttingen, investigated mice with a modified genetic background. The animals showed behavioural disorders and brain deposits that are typically associated with Alzheimer's disease. The researchers went a step further with a group of other animals by removing the genes responsible for the production of the HDAC6 enzyme (histone deacetylase 6). This intervention proved to be effective: while these mice also exhibited the pathological features of Alzheimer's disease in the brain, their behaviour was significantly ameliorated. "The animals' ability to learn and to find their spatial bearings was relatively normal," says Prof. Fischer. "Their cognitive abilities were fully comparable to those of healthy mice."

Improved cellular traffic

In the researchers' view, this effect is at least partly attributable to the fact that important transport processes within the nerve cells are facilitated when the HDAC6 enzyme is not around. This meant in particular that the cells' power plants, also known as "mitochondria," can travel to their final destinations. "It is known that in various neurodegenerative diseases cellular transport is no longer functional. The substances that are to be transported along axons are left behind," Fischer says. "Measures which improve trafficking seem to have a positive effect."

Possible target for therapy?

The researchers' findings suggest that the HDAC6 enzyme could be a possible target for therapies against Alzheimer's disease. However, treatments would require an active substance that can disable the enzyme in a targeted fashion. Unfortunately, the active substances known to date are too unspecific. Prof. Fischer explains that their application resembles a broad-spectrum treatment: "We don't know precisely what is the therapeutic effect of the inhibitors, since they simultaneously block several enzymes from the histone deacetylase family," he says. "And we still don't know enough about how the individual enzymes function."

Improving the accuracy of the inhibitors is therefore the aim of further research. "We will continue to work toward this goal. On one hand, we want to improve our understanding of how the various histone deacetylases function. On the other hand, we want to test inhibitors that operate in a more targeted manner," says Prof. Andr? Fischer.

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Story Source:

The above story is reprinted from materials provided by Helmholtz Association of German Research Centres.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Nambirajan Govindarajan, Pooja Rao, Susanne Burkhardt, Farahnaz Sananbenesi, Oliver M. Schl?ter, Frank Bradke, Jianrong Lu, Andr? Fischer. Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease. EMBO Molecular Medicine, 2012; DOI: 10.1002/emmm.201201923

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/ljCUFV1QTrs/121130121600.htm

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Syrian jets bomb rebels in Damascus

BEIRUT (Reuters) - Syrian jets bombed rebel-held areas of Damascus on Saturday, residents said, and a countrywide Internet blackout entered its third day.

Syrian rebels fighting to oust President Bashar al-Assad clashed with troops in most populated areas of the country, according to opposition activists. At least 40,000 people have been killed during the 20-month-old uprising, they say.

The Syrian Observatory for Human Rights, an opposition-linked monitor, said war planes were bombing the Damascus suburbs of Kafar Souseh and Darraya.

If rebels maintain a presence in these areas, they will hold ground in a continuous arc from the northeast to southwest of the capital's outer districts.

"Syrian regular forces are trying to control the areas surrounding the capital and clashed with rebel fighters," the Observatory said.

The mostly Sunni Muslim rebels battling Assad, who is from Syria's Alawite minority linked to Shi'ite Islam, have been making gains across Syria by overrunning military bases and have been ramping up attacks on Damascus, his seat of power.

Since Thursday, clashes have been reported near the Aqraba and Babilla districts on the southeastern outskirts of Damascus which lead to the international airport, effectively closing the road and leading EgyptAir and Emirates to suspend flights.

Syrian state television quoted a ministry of information statement saying the Damascus international airport was open on Saturday and that the road leading to it was safe. Opposition activists said clashes continued.

Networking experts accuse the government of cutting off the Internet but Damascus blames "terrorists," a term it uses for the opposition.

Rights groups have warned the communications drop off is a precursor to a wider offensive by government forces in the capital. Syrian security sources and diplomats say the government intends to block central Damascus from the restive suburbs.

Rebels and activists said on Saturday there have been multiple communications problems since the uprising began.

Abu Yazen, an activist from the central city of Homs, said rebel units had been using satellite phones, radios and Skype to coordinate with each other.

"There is no Internet or phone service in Syria but it has not affected our work too much," he told Reuters over Skype.

Activists reported clashes and aerial strikes in the provinces of Homs, Deir al-Zor, Idlib and in Aleppo where they said 14 rebels fighters were killed during an assault on an army base in the town of Khanasser early on Saturday.

(Reporting by Oliver Holmes; Editing by Janet Lawrence)

Source: http://news.yahoo.com/syrian-jets-bomb-rebels-internet-down-third-day-113622908.html

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