Tuesday, April 30, 2013

Frequently used biologic agents might cause acute liver injury

Apr. 29, 2013 ? A commonly used class of biologic response modifying drugs can cause acute liver injury with elevated liver enzymes, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association. Patients with inflammatory diseases such as Chron's disease or ulcerative colitis often are prescribed tumor necrosis factor-alpha (TNF-?) antagonists, which modify the body's response to infection. Patients with inflammatory arthropathies and selected dermatological diseases are also candidates to receive such compounds.

"TNF-? antagonists are extremely beneficial as therapies for several bowel, joint and skin inflammatory conditions," said Maurizio Bonacini, MD, AGAF, study author and associate clinical professor, University of California, San Francisco. "However, gastroenterologists, internists, rheumatologists and dermatologists all need to be aware of this potential complication and know how to diagnose it. They should conduct tests for autoimmunity early upon diagnosis of abnormalities to determine the proper path of care."

Researchers searched the U.S. Drug-Induced Liver Injury Network database and identified six well-characterized cases of drug-induced liver injury (DILI) in the setting of TNF-? antagonist therapy. Additionally, they reviewed 28 additional cases identified in PubMed. The researchers found acute liver injury in all cases, most frequently autoimmunity and hepatocellular injury, but mixed non-autoimmune patterns and cholestasis (blocked flow of bile from the liver) also occurred. No deaths were attributed to the liver injury; one patient required a liver transplant, which was attributed to pre-existing cirrhosis with superimposed DILI.

Of the TNF-? antagonists, infliximab-associated liver injury has been the best documented, most likely because of its earlier approval and more wide-spread clinical use. Etanercept and adalimumab have also been linked to drug-induced liver injury. So far, there are no published cases found to be linked to natalizumab, golimumab or certolizumab.

The researchers found that liver damage was typically resolved following drug discontinuation, although some patients did benefit from a course of corticosteroids. Importantly, patients treated with an alternative TNF-? after resolution of their liver injury appeared to tolerate the drugs without recurrence.

"If patients who are taking these biologic agents experience symptoms such as abdominal pain, nausea and fatigue, physicians should check liver enzyme levels to determine if the symptoms are a result of these drugs," added Dr. Bonacini.

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Story Source:

The above story is reprinted from materials provided by American Gastroenterological Association, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Marwan Ghabril, Herbert L. Bonkovsky, Clarissa Kum, Tim Davern, Paul H. Hayashi, David E. Kleiner, Jose Serrano, Jim Rochon, Robert J. Fontana, Maurizio Bonacini. Liver Injury From Tumor Necrosis Factor-? Antagonists: Analysis of Thirty-four Cases. Clinical Gastroenterology and Hepatology, 2013; 11 (5): 558 DOI: 10.1016/j.cgh.2012.12.025

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/ZXJuWf8KuwY/130429164926.htm

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Work Hard On Your Own Home Improvement Right now | Articles ...

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Jony Ive once again rumored to be painting a kinder, flatter iOS 7 interface

Jony Ive once again rumored to be painting a kinder, flatter iOS 7 interface

We've been hearing about Jony Ive taking a sand blaster to iOS 7 -- removing a lot of the heavier textures, gradients, shadows, and skeuomorphs that built up at Apple under Steve Jobs and Scott Forstall. According to what I've been hearing, iOS 7 will make fans of the richer design style cry. 9to5Mac's ace reporter, Mark Gurman calls it Windows Phone-like, and what's more:

In addition to losing the complex interface design characteristics from earlier versions of iOS, Apple has been discussing and testing ways to add more ?glance-able? information and system options panels, like Notification Center, to the software. While it is still uncertain if Apple will end up including such new functionality in iOS 7, or how the Company will implement the potential addition, one of the early ideas was to implement the new panels via swipes from the left and right side of an iOS device?s display. This would be similar to the gesture on Apple?s Mac trackpads for accessing Notification Center in Mountain Lion, but what, specifically, the iOS gesture could access is uncertain.

Gurman also says that iOS 7 is code-named Innsbruck, and includes a full set of newly redesigned icons for the built-in Apple apps. As that suggests, and as I've heard as well, the Springboard launcher and its grid aren't going anywhere any time soon, so those hoping for an entirely new Home screen experience will be disappointed, at least this time around.

What this means for developers and designers, post iOS 7, will depend on how they've built their apps to date. Those who have stuck to UIKit will get a lot of the new look, including all the new stock interface elements, "for free". Those who have replicated UIKit elements in order to customize them will have to re-replicate them. Those who have custom interfaces who want to fit the new aesthetic will have a lot of graphics to redraw come WWDC.

Ironically, Windows Phone and Android went flat to overcome performance issues. Compositing, masking, and shadow effects take cycles. Flat interface can be thrown around much faster. Yet because they've done it more recently, and because it stands in contrast to the more elaborate 2007-esque iOS interface, it looks "new". Their constraints brought out a cleanness and modernness that became fashionable, and now Apple looks decidedly unfashionable by contrast.

It'd be tempting to call the move reactionary -- a new look by new management to deal with new tastes in the market -- but for the new management being headed by Jony Ive. His tastes are well known, minimalist and timeless, getting everything, every distraction, out of the way until only the essential essence of the thing remains. We're simply seeing that vision, Ive's vision, applied to software for the first time. That it's a stark contrast, and likely a welcome change for many from the status quo, is a bonus.

Check out Gurman's article for more on iOS 7's new look, and then come back here and let me know what you think. If Apple goes flat, should they go very flat?

Source: 9to5Mac

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/P5QO6_uBecQ/story01.htm

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Monday, April 29, 2013

Pathological gambling caused by excessive optimism

Apr. 29, 2013 ? Compulsive gamblers suffer from an optimism bias that modifies their subjective representation of probability and affects their decisions in situations involving high-risk monetary wagers. This is the conclusion drawn by Jean-Claude Dreher's research team at the CNC (Centre de Neurosciences Cognitives, CNRS / Universit? Claude Bernard Lyon 1). These findings, published in the May print edition of Psychological Medicine, could help explain and anticipate certain individuals' vulnerability to gambling, and could lead to new therapeutic approaches.

A growing number of gamblers suffer from pathological gambling, a disease that is usually characterized as either a loss of impulse control or a behavioral addiction. It results in an inability to limit the frequency of gambling and the amount of money wagered. This increasingly common psychiatric disorder creates financial, professional and personal hardships that can have severe consequences for the patients and the people around them. The mechanisms responsible for its emergence and development remain largely unknown, which limits the clinician's ability to proceed with a diagnosis, prognosis or effective treatment for this condition.

In this study, the researchers set out to test and verify the hypothesis that links pathological gambling to an alteration of probabilistic reasoning. The capacity to reason in probabilistic terms appears only at an advanced stage of human intellectual development (in fact, the basic concept of probability is not fully understood until the age of 11 or 12). Pioneering research in the late 1970s had already shed light on the difficulties that people experience in situations involving risk or uncertainty. These difficulties are reflected in the development and perpetuation in adults of cognitive biases1 specific to probabilistic decision-making, one of the most common being probability distortion (2).

The researchers conducted an experiment on compulsive gambling patients using a standard experimental economics task and a mathematical model for measuring both probability distortion and a more general optimism bias in relation to high-risk bets. The primary result obtained confirms the general hypothesis of a distortion, associated with pathological gambling, in the subjective representation of probabilities. The results also show that the compulsion to gamble is not explained by an exaggerated distortion of probability, but rather by an increased optimism bias. In other words, regardless of the objective probability of winning a high-risk bet, gamblers tend to act as though this probability were greater than it actually is. The researchers also observed that in the patient population under study, the intensity of this bias was significantly correlated to the severity of the symptoms.

For clinical psychiatrists, the simplicity of the procedure used to reach this conclusion could offer a rapid and reliable way of measuring the representation of probability, thus allowing them to refine both their diagnoses and therapeutic decisions. This study raises many new questions for researchers in the cognitive neurosciences: how does the brain represent the probability of winning? How do the cerebral structures responsible for this representation interact with the structures involved in the development and perpetuation of an addiction? Is a pathological gambler's particular relationship to probability accompanied by an increased sensitivity to reward and/or insensitivity to monetary loss? These important questions are now being investigated at the CNC.

(1) Internal or external influence causing an alteration of human judgment or perception.

(2) Identified by the Nobel laureates Kahneman and Tversky in 1979, probability distortion is characterized by the overestimation of low probabilities and underestimation of high probabilities.

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Story Source:

The above story is reprinted from materials provided by CNRS (D?l?gation Paris Michel-Ange).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. R. Ligneul, G. Sescousse, G. Barbalat, P. Domenech, J.-C. Dreher. Shifted risk preferences in pathological gambling. Psychological Medicine, 2012; 43 (05): 1059 DOI: 10.1017/S0033291712001900

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/6ThD_ZBimlQ/130429102400.htm

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Steady rain greets Jazz Fest as 1st weekend closes

(AP) ? A steady, sometimes heavy rain pelted fans at the New Orleans Jazz and Heritage Festival, but the music flowed on.

Umbrellas, rain boots and plastic ponchos were out in abundance Sunday as fans stood among the puddles and water-soaked grass awaiting clearer skies.

As Khris Royal & Dark Matter played the Gentilly Stage, pockets of fest-faithfuls grooved and danced to his funky saxophone opening instrumental. Keith Frank & the Soileau Zydeco Band enticed fans to the front of the nearby Fais Do-Do stage, where a few couples rocked a two-step to the band's steady beat.

The Nevilles, without brother Aaron, perform later Sunday just before the Dave Matthews Band, which closes the fest's first weekend and largest stage.

Other headliners include blues legend B.B. King and Earth, Wind & Fire.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-04-28-US-Music-Jazz-Fest/id-afe61fa0f1444103b01205eaaaebcf56

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3 Taliban bombs target Pakistani politicians

PARACHINAR, Pakistan (AP) ? Taliban bombs targeting politicians in northwestern Pakistan on Sunday killed 11 people, the latest in a series of attacks meant to disrupt next month's parliamentary election, police said.

The wave of political violence has killed at least 60 people in recent weeks, and many of the attacks have been directed at candidates from secular parties opposed to the Taliban. That has raised concern the violence could benefit hard-line Islamic candidates and others who are more sympathetic to the Taliban because they are able to campaign more freely without fear of being of being attacked.

Pakistani Taliban spokesman Ahsanullah Ahsan claimed responsibility for the three attacks, plus two others against secular parties in the southern port city of Karachi on Saturday that killed four people and wounded over 40.

"We are against all politicians who are going to become part of any secular, democratic government," Ahsan told The Associated Press by telephone from an undisclosed location.

The first bomb on Sunday ripped through the campaign office of Syed Noor Akbar on the outskirts of Kohat city, killing six people and wounding 10, police officer Mujtaba Hussain said.

A second bomb targeted the office of another candidate, Nasir Khan Afridi, in the suburbs of Peshawar city. That attack killed three people and wounded 12, police officer Saifur Rehman said.

The politicians were not in their offices at the time of the blasts. They are both running as independent candidates for parliament to represent constituencies in Pakistan's rugged tribal region along the Afghan border, the main sanctuary for Taliban and al-Qaida militants in the country.

Many politicians running in the May 11 election from the tribal region have their offices located elsewhere and find it hard to campaign in their constituencies because of the danger. The two who were attacked Sunday are considered to hold relatively progressive views compared to the deeply conservative Islamic beliefs of many in the tribal region.

The third attack occurred in the town of Swabi, where a bomb went off during a small rally held by the Awami National Party, which has been repeatedly targeted by the Taliban. The blast killed two people and wounded five, said police officer Farooq Khan. The two candidates targeted in the attack, Ameer Rehman and Haji Rehman, were not hurt.

The Pakistani Taliban have been waging a bloody insurgency against the government for years that has killed thousands of civilians and security personnel. The group's goal is to oust Pakistan's democratic government and implement a system based on Islamic law.

In mid-March, the Taliban threatened attacks against three secular parties that have earned the militants' ire by supporting military operations against them in the northwest: the Awami National Party, the Muttahida Quami Movement and the Pakistan People's Party. The Taliban have carried out at least 20 attacks against politicians and campaign workers since then, mostly from these three parties.

The violence has forced the parties to close dozens of campaign offices and has prevented them from holding large political rallies that are normally the hallmark of Pakistani elections. Many of the candidates have had to find ways to campaign from a distance, relying more on social media, advertisements and even short documentaries to rally support.

That has put these candidates at a disadvantage, and many have complained the militant violence amounts to vote rigging.

Candidates from Islamic parties and others who have advocated negotiating peace with the militants rather than fighting them have been able to campaign with much less fear of being attacked.

Former Prime Minister Nawaz Sharif, head of the Pakistan Muslim League-N party, held a rally with several thousand people in the northern town of Murree on Sunday without incident. Many analysts predict Sharif's party will come out on top in the parliamentary election.

The Taliban issued a statement earlier this year requesting that Sharif and the heads of the country's two largest Islamic parties mediate peace negotiations. Sharif declined but said he was a supporter of the talks.

The parties that have been targeted by the Taliban also support peace negotiations with the militants, but only if they lay down their weapons and accept the constitution first ? conditions the militant group has rejected.

____

Associated Press Writers Riaz Khan and Rasool Dawar in Peshawar contributed to this report.

Source: http://news.yahoo.com/3-taliban-bombs-target-pakistani-politicians-172732748.html

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Game Of Tones, The Game That Could Eventually Teach You To Play The Actual Guitar

Screen Shot 2013-04-28 at 11.05.37 PMHot damn, the Disrupt NY 2013 Hackathon was great. Even with the hackathon over and the winner declared (Way to go, Rumbler!), we keep finding more projects we want to highlight. Built in just 24 hours, Game Of Tones is a proof-of-concept game that, with a bit of work, could teach you to play the actual guitar.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/fzGhy79xz5I/

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Mother of bomb suspects found deeper spirituality

In this image taken from a video, an undated family photo provided by Patimat Suleimanova, the aunt of USA Boston bomb suspects, shows Anzor Tsarnaev left, Zubeidat Tsarnaev holding Tamerlan Tsarnaev and Anzor's brother Mukhammad Tsarnaev. Now known as the angry and grieving mother of the Boston Marathon bombing suspects, Zubeidat Tsarnaev is drawing increased attention after federal officials say Russian authorities intercepted her phone calls, including one in which she vaguely discussed jihad with her elder son. In another, she was recorded talking to someone in southern Russia who is under FBI investigation in an unrelated case, U.S. officials said. (AP Photo/Patimat Suleimanova)

In this image taken from a video, an undated family photo provided by Patimat Suleimanova, the aunt of USA Boston bomb suspects, shows Anzor Tsarnaev left, Zubeidat Tsarnaev holding Tamerlan Tsarnaev and Anzor's brother Mukhammad Tsarnaev. Now known as the angry and grieving mother of the Boston Marathon bombing suspects, Zubeidat Tsarnaev is drawing increased attention after federal officials say Russian authorities intercepted her phone calls, including one in which she vaguely discussed jihad with her elder son. In another, she was recorded talking to someone in southern Russia who is under FBI investigation in an unrelated case, U.S. officials said. (AP Photo/Patimat Suleimanova)

FILE - This April 25, 2013 file photo shows the mother of the two Boston bombing suspects, Zubeidat Tsarnaeva, left, speaking at a news conference in Makhachkala, the southern Russian province of Dagestan. Two government officials tell The Associated Press that U.S. intelligence agencies added the Boston bombing suspects' mother to a federal terrorism database about 18 months before the attack. At right is her sister-in-law Maryam. (AP Photo/Musa Sadulayev, File)

BOSTON (AP) ? In photos of her as a younger woman, Zubeidat Tsarnaeva wears a low-cut blouse and has her hair teased like a 1980s rock star. After she arrived in the U.S. from Russia in 2002, she went to beauty school and did facials at a suburban day spa.

But in recent years, people noticed a change. She began wearing a hijab and cited conspiracy theories about 9/11 being a plot against Muslims.

Now known as the angry and grieving mother of the Boston Marathon bombing suspects, Tsarnaeva is drawing increased attention after federal officials say Russian authorities intercepted her phone calls, including one in which she vaguely discussed jihad with her elder son. In another, she was recorded talking to someone in southern Russia who is under FBI investigation in an unrelated case, U.S. officials said.

Tsarnaeva insists there is no mystery. She's no terrorist, just someone who found a deeper spirituality. She insists her sons ? Tamerlan, who was killed in a gunfight with police, and Dzhokhar, who was wounded and captured ? are innocent.

"It's all lies and hypocrisy," she told The Associated Press in Dagestan. "I'm sick and tired of all this nonsense that they make up about me and my children. People know me as a regular person, and I've never been mixed up in any criminal intentions, especially any linked to terrorism."

Amid the scrutiny, Tsarnaeva and her ex-husband, Anzor Tsarnaev, say they have put off the idea of any trip to the U.S. to reclaim their elder son's body or try to visit Dzhokhar in jail. Tsarnaev told the AP on Sunday he was too ill to travel to the U.S. Tsarnaeva faces a 2012 shoplifting charge in a Boston suburb, though it was unclear whether that was a deterrent.

At a news conference in Dagestan with Anzor last week, Tsarnaeva appeared overwhelmed with grief one moment, defiant the next. "They already are talking about that we are terrorists, I am terrorist," she said. "They already want me, him and all of us to look (like) terrorists."

Tsarnaeva arrived in the U.S. in 2002, settling in a working-class section of Cambridge, Mass. With four children, Anzor and Zubeidat qualified for food stamps and were on and off public assistance benefits for years. The large family squeezed itself into a third-floor apartment.

Zubeidat took classes at the Catherine Hinds Institute of Esthetics, before becoming a state-licensed aesthetician. Anzor, who had studied law, fixed cars.

By some accounts, the family was tolerant.

Bethany Smith, a New Yorker who befriended Zubeidat's two daughters, said in an interview with Newsday that when she stayed with the family for a month in 2008 while she looked at colleges, she was welcomed even though she was Christian and had tattoos.

"I had nothing but love over there. They accepted me for who I was," Smith told the newspaper. "Their mother, Zubeidat, she considered me to be a part of the family. She called me her third daughter."

Zubeidat said she and Tamerlan began to turn more deeply into their Muslim faith about five years ago after being influenced by a family friend, named "Misha." The man, whose full name she didn't reveal, impressed her with a religious devotion that was far greater than her own, even though he was an ethnic Armenian who converted to Islam.

"I wasn't praying until he prayed in our house, so I just got really ashamed that I am not praying, being a Muslim, being born Muslim. I am not praying. Misha, who converted, was praying," she said.

By then, she had left her job at the day spa and was giving facials in her apartment. One client, Alyssa Kilzer, noticed the change when Tsarnaeva put on a head scarf before leaving the apartment.

"She had never worn a hijab while working at the spa previously, or inside the house, and I was really surprised," Kilzer wrote in a post on her blog. "She started to refuse to see boys that had gone through puberty, as she had consulted a religious figure and he had told her it was sacrilegious. She was often fasting."

Kilzer wrote that Tsarnaeva was a loving and supportive mother, and she felt sympathy for her plight after the April 15 bombings. But she stopped visiting the family's home for spa treatments in late 2011 or early 2012 when, during one session, she "started quoting a conspiracy theory, telling me that she thought 9/11 was purposefully created by the American government to make America hate Muslims."

"It's real," Tsarnaeva said, according to Kilzer. "My son knows all about it. You can read on the Internet."

In the spring of 2010, Zubeidat's eldest son got married in a ceremony at a Boston mosque that no one in the family had previously attended. Tamerlan and his wife, Katherine Russell, a Rhode Island native and convert from Christianity, now have a child who is about 3 years old.

Zubeidat married into a Chechen family but was an outsider. She is an Avar, from one of the dozens of ethnic groups in Dagestan. Her native village is now a hotbed of an ultraconservative strain of Islam known as Salafism or Wahabbism.

It is unclear whether religious differences fueled tension in their family. Anzor and Zubeidat divorced in 2011.

About the same time, there was a brief FBI investigation into Tamerlan Tsarnaev, prompted by a tip from Russia's security service.

The vague warning from the Russians was that Tamerlan, an amateur boxer in the U.S., was a follower of radical Islam who had changed drastically since 2010. That led the FBI to interview Tamerlan at the family's home in Cambridge. Officials ultimately placed his name, and his mother's name, on various watch lists, but the inquiry was closed in late spring of 2011.

After the bombings, Russian authorities told U.S. investigators they had secretly recorded a phone conversation in which Zubeidat had vaguely discussed jihad with Tamerlan. The Russians also recorded Zubeidat talking to someone in southern Russia who is under FBI investigation in an unrelated case, according to U.S. officials who spoke on condition of anonymity because they were not authorized to discuss the investigation with reporters.

The conversations are significant because, had they been revealed earlier, they might have been enough evidence for the FBI to initiate a more thorough investigation of the Tsarnaev family.

Anzor's brother, Ruslan Tsarni, told the AP from his home in Maryland that he believed his former sister-in-law had a "big-time influence" on her older son's growing embrace of his Muslim faith and decision to quit boxing and school.

While Tamerlan was living in Russia for six months in 2012, Zubeidat, who had remained in the U.S., was arrested at a shopping mall in the suburb of Natick, Mass., and accused of trying to shoplift $1,624 worth of women's clothing from a department store.

She failed to appear in court to answer the charges that fall, and instead left the country.

___

Seddon reported from Makhachkala, Russia. Associated Press writers Eileen Sullivan and Matt Apuzzo contributed to this report from Washington.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-28-Boston%20Marathon-Suspects'%20Mother/id-2828699e2d4240a797ddb521530b55d4

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Sunday, April 28, 2013

Packers sign Rodgers to $110M contract extension

GREEN BAY, Wis. (AP) ? The Green Bay Packers gave Aaron Rodgers his opportunity when 23 other teams passed.

On another late April weekend with the NFL draft unfolding anew, there was Rodgers again, expressing his appreciation of the Packers for their latest sign of faith.

The Packers signed their franchise quarterback Friday to a five-year contract extension through the 2019 season, eight years after they stopped his slide down the draft board and took him with the 24th pick in the first round. The deal, according to a person with knowledge of the contract who spoke to The Associated Press on condition of anonymity because the team has not released the details, is worth as much as $110 million, with $40 million guaranteed.

Rodgers had two seasons remaining on his current deal for a total of roughly $20 million. So this is essentially a seven-year contract, right there with the $120.6 million that the Baltimore Ravens gave quarterback Joe Flacco last month over six years. Judged by the new part of the deal, Rodgers will be the highest-paid player in NFL history, with an average annual salary of $22 million over those five seasons.

"I'm excited to know my future is here and I'll be here for a lot longer," Rodgers said inside the locker room at Lambeau Field.

Locking up Rodgers was a priority for the Packers, who also reached a long-term extension with linebacker Clay Matthews this month worth as much as $66 million over five years. The Packers are 53-27 in five years with Rodgers as the starter, and he led them to the Super Bowl title following the 2010 season.

President Mark Murphy said leaving enough space under the salary cap to consistently field a competitive team around Rodgers for the life of his deal was "crucial." He also acknowledged that the Packers not only gave Rodgers a market-rate contract but set a new market in the process.

"But he's a pretty good quarterback, too," Murphy said, laughing.

Rodgers, the longest-tenured Packers player, the only one still on the roster from that 4-12 team in 2005, said he's confident the front office will continue to be able to build a winner around him.

"I like where we're at. Obviously, there were some discussions about not doing a lot in free agency," Rodgers said. "Like I said, this seems to be the Packer way where you draft a guy in your system and you pay them."

Rodgers has thrown for 21,661 yards and 171 touchdowns in his career, and he has had a quarterback rating of 101.2 or better in all but one season as a starter. His quarterback rating of 122.5 in 2011 is an NFL record.

The former standout at Cal was expected to be taken early in the first round in 2005, but he soon found himself alone in the green room. Rodgers acknowledged that prove-the-doubters-wrong attitude he's used to his benefit throughout his career since that day he was ignored by so many in the draft.

"I have a good memory, and I'm driven to be the best," Rodgers said. "Obviously, there's a couple less critics out there now, but I still put a lot of pressure on myself to achieve the goals I set for myself here and enjoy trying to meet the challenge that those goals bring and also opposing teams bring."

Draft day wasn't the only rough spot for Rodgers in his career.

He arrived in Green Bay as the backup to Brett Favre, who wasn't thrilled the team had found his heir apparent. Favre kept fans and the franchise on their toes every offseason from then on, flirting with the idea of retiring but always coming back. When the tension finally snapped in 2008 ? Favre retired, changed his mind and asked for his job back ? Rodgers found himself in the middle of the most-bitter divorce in Wisconsin history.

Favre was traded to the New York Jets during training camp, but many fans remained loyal to him. They took their anger at the organization out on Rodgers, even booing him at the team's "Family Night" scrimmage. Rodgers kept his composure, never firing back at fans or even publicly criticizing Favre.

Despite a 6-10 record in his first year as a starter, he showed flashes of why general manager Ted Thompson had such faith in him, and fans began to come around. Any lingering animosity disappeared after Favre joined the rival Minnesota Vikings and Rodgers led the Packers to the playoffs following the 2009 season.

Now? He's of the most beloved figures in the state's rich sports history. The Wisconsin Legislature designated Dec. 12, 2012, as "Aaron Rodgers Day," and students and workers throughout the state were encouraged to celebrate by wearing his jersey. When he was shown on the scoreboard at the Milwaukee Bucks' playoff game against the Miami Heat on Thursday, he got one of the biggest cheers of the night.

Rodgers will be 36 when the deal ends. He said he thinks he has at least eight years left in his legs and his body, when asked if wondered if this would be his last contract.

"A lot of times you don't see a deal all the way through if you're playing well. It's just the nature of some of these contracts. That's a long way off. In order to even get to that conversation, it's going to take many years in a row at a consistently high level of play for me, which I expect to do," Rodgers said. "And I'm going to get myself in the best shape mentally and physically to do that, and hopefully we can have that conversation in seven years where I can still play and maybe we can keep this thing going."

___

AP Pro Football Writer Barry Wilner in New York and AP National Writer Nancy Armour from Milwaukee contributed to this report.

___

Online: http://www.pro32.ap.org

Source: http://news.yahoo.com/packers-sign-rodgers-110m-contract-extension-225159904.html

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Murder suspect missing since 1999 surrenders

LAWTON, Okla. (AP) ? Authorities say a murder suspect who's been on the run since a brazen escape from an Oklahoma jail with eight other inmates in 1999 has turned himself in.

David Lee Kemp was the only inmate to elude capture after escaping the Comanche County jail on March 11, 1999. He was awaiting trial on two first-degree murder counts in the killings of his ex-wife and her boyfriend. Authorities say the inmates escaped after overpowering a guard using a large barbecue fork.

Comanche County Sheriff Kenny Stradley says Kemp, 43, was arrested early Friday. Comanche County is 80 miles southwest of Oklahoma City.

The FBI says Kemp was spotted in Las Vegas and may have visited Phoenix and Louisiana. FBI spokesman Rick Rains says Kemp turned himself in.

Source: http://news.yahoo.com/inmate-missing-since-1999-surrenders-oklahoma-162641201.html

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Obama pokes fun at himself at Correspondents' Dinner

WASHINGTON (AP) ? President Barack Obama joked Saturday about his plans for a radical second-term evolution from a "strapping young Muslim Socialist" to retiree golfer, all with a new hairstyle like first lady Michelle's.

Obama used this year's annual White House Correspondents' Association dinner to poke fun at himself and some of his political adversaries, asking if it was still possible to be brought down a peg after 4? years as commander-in-chief.

Entering to the rap track "All I Do Is Win" by DJ Khaled, Obama joked about how re-election would allow him to unleash a radical agenda. But then he showed a picture of himself golfing on a mock magazine cover of "Senior Leisure."

"I'm not the strapping young Muslim Socialist that I used to be," the president remarked, and then recounted his recent 2-for-22 basketball shooting performance at the White House Easter Egg hunt.

But Obama's most dramatic shift for the next four years appeared to be aesthetic. He presented a montage of shots featuring him with bangs similar to those sometimes sported by his wife.

Obama closed by noting the nation's recent tragedies in Massachusetts and Texas, praising Americans of all stripes from first responders to local journalists for serving the public good.

Saturday night's banquet not far from the White House attracted the usual assortment of stars from Hollywood and beyond. Actors Kevin Spacey, Julia Louis-Dreyfus and Claire Danes, who play government characters on series, were among the attendees, as was Korean entertainer Psy. Several Cabinet members, governors and members of Congress were present.

And despite coming at a somber time, nearly two weeks after the deadly Boston Marathon bombing and 10 days after a devastating fertilizer plant explosion in West, Texas, the president and political allies and rivals alike took the opportunity to enjoy some humor. Late-night talk-show host Conan O'Brien headlined the event.

Some of Obama's jokes came at his Republican rivals' expense. He asked that the GOP's minority outreach begin with him as a "trial run" and said he'd take his recent charm offensive with Republicans on the road, including to a book-burning event with Rep. Michele Bachmann.

Casino magnate Sheldon Adelson would have had better success getting Obama out of office if he simply offered the president $100 million to drop out of last year's race, Obama quipped.

And on the 2016 election, the president noted in self-referential irony that potential Republican candidate Sen. Marco Rubio wasn't qualified because he hasn't even served a full term in the Senate. Obama served less than four years of his six-year Senate term before he was elected president in 2008.

The gala also was an opportunity for six journalists, including Associated Press White House Correspondent Julie Pace, to be honored for their coverage of the presidency and national issues.

The New Yorker's Ryan Lizza won the Aldo Beckman Award, which recognizes excellence in the coverage of the presidency.

Pace won the Merriman Smith Award for a print journalist for coverage on deadline.

ABC's Terry Moran was the winner of the broadcast Merriman Smith Award for deadline reporting.

Reporters Jim Morris, Chris Hamby and Ronnie Greene of the Center for Public Integrity won the Edgar A. Poe Award for coverage of issues of national significance.

Source: http://news.yahoo.com/obama-jokes-radical-2nd-term-changes-023742499.html

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Saturday, April 27, 2013

10 Things to Know for Today

Bangladesh rescuers look for survivors and victims at the site of a building that collapsed Wednesday in Savar, near Dhaka, Bangladesh,Thursday, April 25, 2013. By Thursday, the death toll reached at least 194 people as rescuers continued to search for injured and missing, after a huge section of an eight-story building that housed several garment factories splintered into a pile of concrete. (AP Photo/A.M.Ahad)

Bangladesh rescuers look for survivors and victims at the site of a building that collapsed Wednesday in Savar, near Dhaka, Bangladesh,Thursday, April 25, 2013. By Thursday, the death toll reached at least 194 people as rescuers continued to search for injured and missing, after a huge section of an eight-story building that housed several garment factories splintered into a pile of concrete. (AP Photo/A.M.Ahad)

Ministry for Emergency Situations workers and fire fighters work at a site of a fire of a psychiatric hospital Friday morning, April 26, 2013. At least 38 people died in the fire in the psychiatric hospital outside Moscow late Thursday night. Police said the fire, which broke out at about 2 a.m. local time (6 p.m. Eastern, 2200 GMT) in the one-story hospital in the Ramenskoye settlement, was caused by a short circuit. (AP Photo/Pavel Sergeyev)

New York City Police Commissioner Raymond Kelly, left, and Mayor Michael Bloomberg hold a news conference, Thursday, April, 25, 2013 in New York. The two say the Boston Marathon bombing suspects intended to blow up their remaining explosives in Times Square. They said Dzhokhar Tsarnaev told Boston investigators from his hospital bed that he and his brother had discussed going to New York to detonate their remaining explosives. (AP Photo/Mark Lennihan)

Your daily look at late-breaking news, upcoming events and the stories that will be talked about today:

1. BOMB SUSPECTS ALLEGEDLY TARGETED TIMES SQUARE

NYC's mayor and its top cop say the Boston suspects' plan to visit the Big Apple wasn't just "to party" after all.

2. MILLIONS POUR IN TO HELP BOSTON VICTIMS

People who lost limbs will face some of the biggest medical expenses ? artificial legs can cost more than $50,000 each.

3. HOW A COLLAPSED BANGLADESH BUILDING WILL IMPACT THE GARMENT INDUSTRY

With at least 290 dead, there's a renewed look at the conditions at the country's clothing manufacturers.

4. 38 DEAD IN RUSSIA AFTER PSYCHIATRIC HOSPITAL BLAZE

A nurse and two patients are believed to be the only survivors.

5. FIERY AFGHAN BUS CRASH KILLS 30 IN AFGHANISTAN

The bus collided with a truck left burning by the Taliban and could not stop.

6. WHAT PROPELLED GAY MARRIAGE TO VICTORY IN RHODE ISLAND

The savvy political campaign ? including bare-knuckle tactics ? could serve as a model for similar efforts in other states.

7. HISTORIC DROUGHT IS HISTORY

Spring rains soaking the central U.S. have washed away the worst dry spell in decades.

8. WHY THE TOP WINNER WASN'T THE FOCUS AT BILLBOARD LATIN AWARDS

While Reggaeton star Don Omar took home 10 prizes, homage to the late Mexican-American singer Jenni Rivera captured everyone's attention.

9. WHO'S NO. 1

The Kansas City Chiefs take offensive tackle Eric Fisher of Central Michigan as the top pick in the NFL draft.

10. NO MORE WOODER IN PHILUFFYA?

A linguistics professor says the Philadelphia dialect is evolving into a more northern accent

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-26-10-Things-to-Know-Today/id-461988ecdaab45f1ba4bea55047916da

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Syrian officials deny use of chemical weapons

DAMASCUS, Syria (AP) ? Two Syrian officials denied Friday that government forces had used chemical weapons against rebels, the first response from President Bashar Assad's regime to U.S. assertions that it had deployed such weapons during the 2-year-old civil war.

On Thursday, the White House and other top Obama administration officials said that U.S. intelligence had concluded with "varying degrees of confidence" that the Syrian government has twice used chemical weapons in its battle against rebels trying to oust Assad.

In the Syrian capital of Damascus, a government official said Assad's military "did not and will not use chemical weapons even if it had them." Instead, he accused opposition forces of using them in a March attack on the village of Khan al-Assal outside of the northern city of Aleppo, the largest in Syria. The official said the Syrian army had no need to use chemical weapons because it can reach any area in Syria it wants without them.

He spoke to The Associated Press on condition of anonymity because he was not authorized to give official statements.

His comments were echoed by Sharif Shehadeh, a Syrian lawmaker, who said the Syrian army "can win the war with traditional weapons" and has no need for chemical weapons.

Syria's official policy is not to confirm nor deny it has chemical weapons.

Shehadeh called the U.S. claims "lies" and likened them to false accusations that Iraq possessed weapons of mass destruction ? a claim U.S. policymakers had used to justify the invasion of that country in 2003.

"What is being designed for Syria now is similar to what happened in Iraq when Colin Powell lied in the Security Council and said Iraq possesses weapons of mass destruction prior to the U.S. invasion and occupation of that country," he said.

President Barack Obama has said that the use of chemical weapons would be a "red line" that could result in a significant military response. But the administration said on Thursday that the new revelation won't immediately change its stance on intervention.

Following the Khan al-Assal attack, the government called for the United Nations to investigate alleged chemical weapons use by rebels.

Syria, however, has still not allowed a team of experts into the country because it wants the investigation limited to the single Khan al-Assal incident while U.N. Secretary-General Ban Ki-moon is urging the Syrian government to accept an expanded U.N. probe into alleged chemical weapons use.

"They want this team to be similar to the inspection teams in Iraq that destroyed the country after it became clear that it was all a great lie," Information Minister Omran al-Zoubi said in comments published on Syria's state-run news agency SANA.

On the streets of Damascus, the conflict dragged on Friday. Government troops pushed into two northern neighborhoods, triggering heavy fighting with rebels as they tried to advance under air and artillery support, activists said. The drive was the latest in a days-long offensive by government forces in and around the capital, an apparent bid to secure Assad's main stronghold against rebel challenges.

The Britain-based Syrian Observatory for Human Rights said the fighting between rebels and soldiers backed by pro-government militiamen was concentrated in the Jobar and Barzeh areas. The Local Coordination Committees, another activist group, said troops also used mortars and multiple rocket launchers to bombard the nearby neighborhood of Qaboun.

SANA said troops killed five rebels in clashes near the main mosque in Jobar. It added that many other "terrorists," the term the government uses for rebels, were killed in the area and the nearby neighborhood of Zamalka.

The regime has largely kept the rebels at bay in Damascus, although opposition fighters control several suburbs of the capital from which they have threatened the heart of the city. Last month, government troops launched a campaign to repel the opposition's advances near the capital, deploying elite army units to the rebellious suburbs and pounding rebel positions with airstrikes.

The Observatory also reported clashes in Aleppo between rebels and Kurdish gunmen in the contested Sheikh Maqsoud neighborhood. It also said there was fighting around the sprawling Abu Zuhour air base in the northwestern Idlib province.

Syria's conflict started with largely peaceful protests against Assad's regime in March 2011 but later degenerated into a civil war, which has left an estimated 70,000 dead.

___

AP reporter Zeina Karam and Bassem Mroue contributed from Beirut.

Source: http://news.yahoo.com/syrian-officials-deny-chemical-weapons-113003061.html

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Toshiba to release 4K-ready, 160MB/s CompactFlash memory cards

Toshiba to release CompactFlash memory cards with 150MBs write speed

Toshiba will launch its Exceria Pro series of CompactFlash cards into the Japanese market tomorrow with 160MB/s read speeds and 150MB/s write speeds. The company claims the 32GB and 64GB models are the fastest CF cards you can get now, thanks to the UDMA7 protocol combined with its own NAND flash memory and custom firmware. As such, it's certified them to the "video performance guarantee profile 2" (VPG-65) standard, meaning they're guaranteed to sustain 65MB/s, which Toshiba says will support many CF-equipped 4K cameras on the market. Obviously, HD and RAW still shooters using pro DSLR models like Canon's 5D Mark III and the Nikon D800 won't have to sweat the frames-per-second, either. There's no word on US availability or pricing, but we should know more when they hit Japanese shops on April 27th.

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Source: http://www.engadget.com/2013/04/26/toshiba-compact-flash-exceria-pro-150MBps/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Friday, April 26, 2013

Qualcomm's Snapdragon 800 to enter mass production in late May

Qualcomm's Snapdragon 800 to enter mass production in late May

While Snapdragon 600 is already showing up on various flagship devices like the HTC One, PadFone Infinity, Galaxy S 4, Optimus G Pro and Xiaomi 2S, we're still looking forward to the big daddy of Qualcomm's lineup this year: the Snapdragon 800. At a media event in Beijing earlier today, Senior Product Manager Yufei Wang confirmed that his company's next flagship SoC will enter mass production in late May, but he refused to comment on which upcoming devices will feature it. And due to the current state of the silicon (even though vendors like ZTE are already sampling it), we weren't allowed to run any benchmark tests on the Snapdragon 800 development devices on display just yet, though we've been told to stay tuned in June.

What makes the 800 shine brighter than the 600 is its more powerful Krait 400 architecture, which can maintain a clock speed of up to 2.3GHz; but like before, the four cores are also clocked asynchronously for better power management. On top of that, the 800 comes with the new Adreno 330 graphics processor with 30fps 4K playback capability, while still featuring the improved Adreno 320's FlexRender technology that can dynamically switch between direct rendering and binning rendering for optimized performance and efficiency. We'll save the nitty-gritty for the proper launch of this 28nm chip later this year.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/mHAptKdZPsE/

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Ubuntu 13.04 available Thursday, brings a streamlined footprint to the forefront (update)

Ubuntu 1304 available tomorrow, brings a streamlined footprint to the forefront

From an end user's perspective, it's always nice to see developers take a step back and focus on streamlining their code, rather than simply piling on new features. Apple used the strategy to great success with Snow Leopard, and now Canonical is set to follow suit with Raring Ringtail, also known as Ubuntu 13.04. The latest version of the popular Linux distro is set for general availability tomorrow, which follows a beta release and a controversial amount of secrecy. Raring Ringtail is characterized as "the fastest and most visually polished Ubuntu experience to date," with a particular emphasis on a smaller memory footprint and greater responsiveness. Much of the streamlining effort was in preparation for Ubuntu's future life in mobile, and to coincide with that effort, developers will find a preview SDK for app development and the ability to test apps within the MIR display server. The release is now a mere hours away, and yes, it'll be a good day.

[Image credit: WebUpd8]

Update: Aaaaaand, it's live!

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Stock futures climb as earnings roll in; claims data on tap

By Chuck Mikolajczak

NEW YORK (Reuters) - Stock index futures advanced on Thursday, as investors dealt with a raft of earnings, including those of 3M Co, along with data on the labor market.

Dow component ExxonMobil Corp , the largest U.S. company by market capitalization reports its results Thursday, a day after the company boosted its quarterly dividend.

Fellow Dow component 3M Co reported a slight rise in profit on modest growth in sales of its wide array of products, but shares fell 4.1 percent to $103.50 in premarket trading.

Qualcomm Inc lost 5.8 percent to $62.20 before the opening bell after the mobile chipmaker forecast earnings below expectations late Wednesday.

"The focus remains on the fact that companies continue to mostly beat expectations for earnings but also, many are disappointing on the forecast," said Rick Meckler, president of investment firm LibertyView Capital Management in Jersey City, New Jersey.

"So it is leaving investors with mixed feelings with no real reason to sell off stocks but not enough of a reason to really drive it materially higher - that pattern is likely to continue for a while."

Companies expected to post earnings after the close include Amazon.com Inc and Starbucks .

Data on the labor market is due at 8:30 a.m. EDT with the release of weekly initial jobless claims data. Economists in a Reuters survey forecast a total of 351,000 new filings compared with 352,000 in the prior week.

Verizon Communications Inc will be in focus after sources told Reuters it has hired advisers to prepare a possible $100 billion cash and stock bid to take full control of Verizon Wireless from joint venture partner, Vodafone Group Plc . Verizon shares edged up 0.4 percent to $52 in light premarket trade.

S&P 500 futures rose 6.4 points and were above fair value, a formula that evaluates pricing by taking into account interest rates, dividends and time to expiration of the contract. Dow Jones industrial average futures added 46 points and Nasdaq 100 futures gained 13.25 points.

PulteGroup Inc , the No. 2 U.S. homebuilder, returned to a quarterly profit after reporting a loss a year earlier, as it benefited from low mortgage rates. Shares fell 2.5 percent to $19.20 in premarket trade.

Akamai Technologies Inc surged 19.4 percent to $43.08 in premarket trading after the internet content delivery company forecast second-quarter results above analysts' expectations late on Wednesday.

Earnings season has been largely positive, with 68.4 percent of S&P 500 companies that have reported results so far beating expectations, according to Thomson Reuters data through Tuesday morning. Since 1994, 63 percent have surpassed estimates on average, while the beat rate is 67 percent for the past four quarters.

Analysts see earnings growth of 3.1 percent this quarter, up from expectations of 1.5 percent at the start of the month.

European shares edged up on Thursday, with the benchmark FTSEurofirst 300 index rising for a fifth straight session, helped by gains in car maker Volkswagen and telecoms group Vodafone <.eu/>

Asian shares rose, with recovering commodities and views that a run of weak global economic data will encourage major central banks to keep or deepen their monetary stimulus improving risk sentiment.

(Editing by Bernadette Baum)

Source: http://news.yahoo.com/stock-index-futures-signal-slightly-higher-open-081750934--finance.html

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Thursday, April 25, 2013

3 Doors Down bassist enters rehab following arrest

A?photo released by the Metropolitan Nashville Police Department is Robert Todd Harrell. Harrell, bassist with the rock band 3 Doors Down has been charged with vehicular homicide by intoxication after an interstate crash claimed the life of another motorist Sunday April 21, 2013, in the Nashville area, police said. (AP Photo/Metropolitan Nashville Police Department)

A?photo released by the Metropolitan Nashville Police Department is Robert Todd Harrell. Harrell, bassist with the rock band 3 Doors Down has been charged with vehicular homicide by intoxication after an interstate crash claimed the life of another motorist Sunday April 21, 2013, in the Nashville area, police said. (AP Photo/Metropolitan Nashville Police Department)

(AP) ? An attorney says 3 Doors Down bassist Robert Todd Harrell has checked himself into drug treatment after being charged with killing someone while driving under the influence.

Attorney Ed Ryan says he could not disclose where Harrell is being treated.

Harrell is facing multiple charges, including vehicular homicide by intoxication. Authorities say he caused a fatal interstate crash in a Nashville suburb last weekend. Records show authorities discovered that Harrell had numerous narcotics on him while he was being processed into the Nashville jail.

Police say the 41-year-old bassist was speeding down Interstate 40 in his Cadillac CTS when he clipped the back of a pickup truck, causing a crash that killed the driver of the truck.

The bassist is due in court next month and is free on bond.

Associated Press

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Colbert Busch leads Sanford in South Carolina congressional race: poll (reuters)

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Wednesday, April 24, 2013

First vaccine to help control autism symptoms

Apr. 24, 2013 ? A first-ever vaccine created by University of Guelph researchers for gut bacteria common in autistic children may also help control some autism symptoms.

The groundbreaking study by Brittany Pequegnat and Guelph chemistry professor Mario Monteiro appears this month in the journal Vaccine.

They developed a carbohydrate-based vaccine against the gut bug Clostridium bolteae.

C. bolteae is known to play a role in gastrointestinal disorders, and it often shows up in higher numbers in the GI tracts of autistic children than in those of healthy kids.

More than 90 per cent of children with autism spectrum disorders suffer from chronic, severe gastrointestinal symptoms. Of those, about 75 per cent suffer from diarrhea, according to current literature.

"Little is known about the factors that predispose autistic children to C. bolteae," said Monteiro. Although most infections are handled by some antibiotics, he said, a vaccine would improve current treatment.

"This is the first vaccine designed to control constipation and diarrhea caused by C. bolteae and perhaps control autism-related symptoms associated with this microbe," he said.

Autism cases have increased almost sixfold over the past 20 years, and scientists don't know why. Although many experts point to environmental factors, others have focused on the human gut.

Some researchers believe toxins and/or metabolites produced by gut bacteria, including C. bolteae, may be associated with symptoms and severity of autism, especially regressive autism.

Pequegnat, a master's student, and Monteiro used bacteria grown by Mike Toh, a Guelph PhD student in the lab of microbiology professor Emma Allen-Vercoe.

The new anti- C. bolteae vaccine targets the specific complex polysaccharides, or carbohydrates, on the surface of the bug.

The vaccine effectively raised C. bolteae-specific antibodies in rabbits. Doctors could also use the vaccine-induced antibodies to quickly detect the bug in a clinical setting, said Monteiro.

The vaccine might take more than 10 years to work through preclinical and human trials, and it may take even longer before a drug is ready for market, Monteiro said.

"But this is a significant first step in the design of a multivalent vaccine against several autism-related gut bacteria," he said.

Monteiro has studied sugar-based vaccines for two other gastric pathogens: Campylobacter jejuni, which causes travellers' diarrhea; and Clostridium difficile, which causes antibiotic-associated diarrhea.

The research was supported by the Natural Sciences and Engineering Research Council.

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The above story is reprinted from materials provided by University of Guelph.

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Journal Reference:

  1. Brittany Pequegnat, Martin Sagermann, Moez Valliani, Michael Toh, Herbert Chow, Emma Allen-Vercoe, Mario A. Monteiro. A vaccine and diagnostic target for Clostridium bolteae, an autism-associated bacterium. Vaccine, 2013; DOI: 10.1016/j.vaccine.2013.04.018

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/0W9_AFl8Wv4/130424112309.htm

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